Study shows Pycnogenol effective against post-spider vein treatment skin discoloration

The new study, published in Minerva Surgery​​, indicated that Pycnogenol may provide cosmetics and personal care product manufacturers with a novel, scientifically backed ingredient to incorporate into their formulations to address skin discoloration and related conditions.

The study investigated the effects of Pycnogenol on post-sclerotherapy hyperpigmentation, a cosmetic side effect that occurs in some patients. Franziska Weichmann, Manager of Scientific Communications and Product Development at Horphag Research, the exclusive worldwide supplier of Pycnogenol, explained, “The aim of this study was to evaluate the effects of the oral supplement Pycnogenol on possible skin discolorations or other minor skin changes after compression sclerotherapy (CS) in comparison with standard management.”

Study design and methodology

The study involved 161 healthy women who underwent CS to treat spider veins, which works by injecting a sclerosing agent into the vein, causing the walls to seal shut and stopping blood flow. While the procedure is minimally invasive, it often results in cosmetic side effects like skin discoloration.

Participants were split into two groups. In one group, consisting of 84 participants, "“Pycnogenol was administered in three 50 mg capsules, starting the day before sclerotherapy and continuing for 12 weeks," said Weichmann. The control group of 77 participants "received standard management without additional drugs," Weichmann continued, and skin discoloration was measured using an analogue scale for the same time period. 

Study findings: lower skin discoloration with pycnogenol

Those who took Pycnogenol experienced significantly less skin discoloration compared to the control group, the study determined. Weichmann highlighted that “Pycnogenol improved healing and prevented skin discoloration post-sclerotherapy, with a lower average skin staining score and fewer discolorations per treated vein compared to the control group.”

The scale used to assess skin staining ranged from 0 (no staining) to 3 (visible staining larger than 1 cm). After 12 weeks, the Pycnogenol group had an average score of 0.4±0.2, while the control group scored 2.1±0.4, a statistically significant difference (P<0.05).

Mechanism of action: Antioxidant and anti-inflammatory properties

The study attributes Pycnogenol’s efficacy to its powerful antioxidant and anti-inflammatory properties. According to Weichmann, Pycnogenol reduces the accumulation of hemosiderin, a pigment formed from the breakdown of red blood cells that contributes to skin discoloration. “By limiting oxidative stress and inflammation, Pycnogenol minimizes the local deposition of iron and formation of free radicals, which are key contributors to skin staining and hyperpigmentation,” she explained.

This mechanism, supported by years of research on the ingredient’s broader skin care benefits, offers significant value for manufacturers seeking to develop products that target post-procedure hyperpigmentation or skin discoloration caused by other factors.

Safety and future research

The study reported no adverse side effects in participants, reinforcing the safety profile of Pycnogenol in both oral and topical applications. With over 40 years of clinical research and more than 50 published studies, Pycnogenol continues to build its reputation as a safe and effective ingredient for various health and skin care concerns, Weichmann reported. 

Looking ahead, she confirmed that further research is planned. “We are committed to continuously exploring its benefits and applications, particularly in skin care, to understand how it can be most effectively utilized,” she said.

For cosmetic manufacturers and suppliers, this ongoing research could open doors to new formulations and applications of Pycnogenol in products designed to treat skin discoloration and enhance overall skin health.

Implications for cosmetic product development

The findings of this study present a valuable opportunity for manufacturers of cosmetics and personal care products to enhance their offerings with a clinically proven ingredient that addresses a widespread cosmetic concern. Pycnogenol is already known for its ability to boost collagen production, hydrate the skin, and brighten complexion, making it a versatile ingredient for skin care products.

Weichmann concluded that regarding ingredient's broader potential “cosmetic products that are looking to provide their customers with a solution for skin discoloration can add Pycnogenol as a clinically proven ingredient. By preventing discoloration amongst its numerous other benefits, Pycnogenol offers a valuable addition to cosmetic products.” 

Source: Minerva Surgery​
2024, 79​(2):161-5, doi: 10.23736/S2724-5691.23.10035-9​
"Pycnogenol prevents skin hyperpigmentation following sclerotherapy"
Authors: M.R. Cesarone, et al.